HistoneDB 2.0 – with variants

This histone database can be used to explore the diversity of histone proteins and their sequence variants in many organisms. The resource was established to better understand how sequence variation may affect functional and structural features of nucleosomes. To get started, select a histone type to explore its variants.


The Nucleosome Core Particle (PDB: 1AOI) is comprised of H2A, H2B, H3, and H4 core histones types, wrapping ~147 bp of DNA. H2A-H2B form a dimer and H3-H4 form a tetramer.