/ Histone type: H2B

Description

H2B is one of the core histones. H2B forms dimers with H2A via the "hand shake" motif. Two H2A-H2B dimers in turn associate with H3-H4 tetramer to form complete nucleosome core. Structure of H2B consists of histone fold with a long flexible N-terminal tail which protrudes between the DNA gyres. H2B interacts with H4 in the nucleosome core via four helix bundle motif. Addtional αC-helix of H2B decorates the surface of nucleosome.

Histone Variants

29 / 13275 canonical H2B
Alternate names: ca H2B
Taxonomic span: Eukaryotes 3 / 658 H2B.1
Alternate names: H2B.1, hTSH2B, TH2B, TS H2B.1
Taxonomic span: Mammals 6 / 389 H2B.W
Alternate names: H2BFWT, member W, type W-T
Taxonomic span: Mammals 2 / 371 H2B.Z
Alternate names: H2Bv
Taxonomic span: Apicomplexa 5 / 80 sperm H2B
Alternate names: cleavage H2B, early H2B
Taxonomic span: Echinoidea(?) 11 / 122 subH2B
Alternate names: H2BL1, subH2Bv
Taxonomic span: Primates, rodents, marsupials, and bovids

Phylogenetic tree of variants (curated sequences)

Above, alignments of curated sequences from all H2B variants have been combined to construct the phylogenetic tree. Most of the variants cluster in separate clades. Click on the taxa name to learn more about its variant.
A set of manually selected and validated histone sequences is listed in the table. Click on an entry in the table to update the annotated sequence preview: a variant will be compared with the canonical histone from the same species (if available). Alternatively, tick mark the sequences and use toolbar to view MSA, export or add to basket. Use search or filters to find particular entries.
Keys: red - identical residues, blue - different residues (if more than one sequence). For feature legend see summary tab.
Sequence preview and annotation... LOADING





Note: variant classification might be ambigous between very similar variants. Classification scores against all variant models are available via advanced menu.
Features characteristic for a given histone type/variant are marked below the consensus sequence. For feature description see summary tabs of the corresponding variants pages.
Keys: red - 80% identical, blue - 50% identical columns. X-ambigous positions in consensus sequence.