/ H2B / canonical H2B

Canonical histones are replication-dependent while histone variants are replication-independent, constitutively expressed during cell cycle. Genes encoding canonical histones are typically located within multigene clusters and use specific type of regulation at the RNA level with a stem loop structure instead of polyA tail
Alternate names: ca H2B
Below, you can explore the features of canonical H2B from Homo sapiens, if available. Canonical histone is shown in the first row, the names and descriptions of each feature can be found underneath. To explore variants from other species, please browse our curated sequences, automatically extracted sequences, or by taxonomy.

Keys: red - identical residues, blue - different residues (if more than one sequence).
R1
Minor groove arginine at alpha1-alpha1 DNA binding site at SHL ±4.5.
alpha1
Alpha1-helix, first helix of histone fold
loopL1
L1 loop, connecting first and second helices of histone fold. Part of the L1L2 DNA binding site formed by H2A and H2B at SHL ±5.5.
beta1
Beta-strand in the L1L2 DNA binding site
alpha2
Alpha2-helix, second helix of histone fold
loopL2
L2 loop, connecting second and third helices of the histone fold. Part of the L1L2 DNA binding site formed by H2A and H2B at SHL ±3.5.
beta2
Beta-strand in the L1L2 DNA binding site
alpha3
Alpha3-helix, third helix of the histone fold
alphaC
AlphaC-helix
  1. Talbert PB, Ahmad K, et al. "A unified phylogeny-based nomenclature for histone variants." Epigenetics Chromatin, 2012. PMID: 22650316
  2. Shaytan AK, Landsman D, et al. "Nucleosome adaptability conferred by sequence and structural variations in histone H2A-H2B dimers." Curr Opin Struct Biol, 2015. PMID: 25731851
Keys: red - identical residues, blue - different residues (if more than one sequence). For feature legend see summary tab.
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Features characteristic for a given histone type/variant are marked below the consensus sequence. For feature description see summary tabs of the corresponding variants pages.
Keys: red - 80% identical, blue - 50% identical columns. X-ambigous positions in consensus sequence.