/ H2B / Variant: H2B.W

Description

H2B.W is involved in spermiogenesis and telomere associated functions in sperm and is found in spermatogenic cells. It has an extended N-terminal tail
Alternate names: H2BFWT, member W, type W-T

Features

Below, you can explore the features of H2B.W from Homo sapiens, if available and how it compares to the canonical histones of the same type (first row). Canonical histone is shown in the first row, the names and descriptions of each feature can be found underneath. To explore variants from other species, please browse our curated sequences, automatically extracted sequences, or by taxonomy.

Keys: red - identical residues, blue - different residues (if more than one sequence).
Variant features
extN
Extended N-terminal tail
General histone type features
R1
Minor groove arginine at alpha1-alpha1 DNA binding site at SHL ±4.5.
alpha1
Alpha1-helix, first helix of histone fold
loopL1
L1 loop, connecting first and second helices of histone fold. Part of the L1L2 DNA binding site formed by H2A and H2B at SHL ±5.5.
beta1
Beta-strand in the L1L2 DNA binding site
alpha2
Alpha2-helix, second helix of histone fold
loopL2
L2 loop, connecting second and third helices of the histone fold. Part of the L1L2 DNA binding site formed by H2A and H2B at SHL ±3.5.
beta2
Beta-strand in the L1L2 DNA binding site
alpha3
Alpha3-helix, third helix of the histone fold
alphaC
AlphaC-helix

References

  1. Talbert PB, Ahmad K, et al. "A unified phylogeny-based nomenclature for histone variants." Epigenetics Chromatin, 2012. PMID: 22650316
  2. Shaytan AK, Landsman D, et al. "Nucleosome adaptability conferred by sequence and structural variations in histone H2A-H2B dimers." Curr Opin Struct Biol, 2015. PMID: 25731851
  3. Lee J, Park HS, et al. "Functional polymorphism in H2BFWT-5'UTR is associated with susceptibility to male infertility." J Cell Mol Med, 2009. PMID: 19583817
  4. Boulard M, Gautier T, et al. "The NH2 tail of the novel histone variant H2BFWT exhibits properties distinct from conventional H2B with respect to the assembly of mitotic chromosomes." Mol Cell Biol, 2006. PMID: 16449661
A set of manually selected and validated histone sequences is listed in the table. Click on an entry in the table to update the annotated sequence preview: a variant will be compared with the canonical histone from the same species (if available). Alternatively, tick mark the sequences and use toolbar to view MSA, export or add to basket. Use search or filters to find particular entries.
Keys: red - identical residues, blue - different residues (if more than one sequence). For feature legend see summary tab.
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Note: variant classification might be ambigous between very similar variants. Classification scores against all variant models are available via advanced menu.
Features characteristic for a given histone type/variant are marked below the consensus sequence. For feature description see summary tabs of the corresponding variants pages.
Keys: red - 80% identical, blue - 50% identical columns. X-ambigous positions in consensus sequence.