/ Histone type: H3

Description

H3 is one of the core histones. Two H3 and two H4 histones form H3-H4 tetramer via "hand shake" and "four helix bundle" motifs. Two H2A-H2B dimers then associate with H3-H4 tetramer to form complete nucleosome core. Structurally H3 has a histone fold domain, αN-helix and a long N-terminal tail with many important post-translational modification sites. The αN-helix organizes the terminal segment of core nucleosomal DNA.

Histone Variants

28 / 3746 canonical H3
Alternate names: ca H3
Taxonomic span: Eukaryotes 14 / 429 cenH3
Alternate names: CENP-A, cid, CNA1, CNP1, Cse4, HCP-3, HTR12
Taxonomic span: Eukaryotes 15 / 1180 H3.3
Alternate names: hv2, soH3-1, soH3-2
Taxonomic span: Eukaryotes 2 / 2419 H3.5
Alternate names: None
Taxonomic span: Hominids 8 / 136 H3.Y
Alternate names: H3.X
Taxonomic span: Primates 2 / 4014 TS H3.4
Alternate names: H3.1t
Taxonomic span: Mammals

Phylogenetic tree of variants (curated sequences)

Above, alignments of curated sequences from all H3 variants have been combined to construct the phylogenetic tree. Most of the variants cluster in separate clades. Click on the taxa name to learn more about its variant.
A set of manually selected and validated histone sequences is listed in the table. Click on an entry in the table to update the annotated sequence preview: a variant will be compared with the canonical histone from the same species (if available). Alternatively, tick mark the sequences and use toolbar to view MSA, export or add to basket. Use search or filters to find particular entries.
Keys: red - identical residues, blue - different residues (if more than one sequence). For feature legend see summary tab.
Sequence preview and annotation... LOADING





Note: variant classification might be ambigous between very similar variants. Classification scores against all variant models are available via advanced menu.
Features characteristic for a given histone type/variant are marked below the consensus sequence. For feature description see summary tabs of the corresponding variants pages.
Keys: red - 80% identical, blue - 50% identical columns. X-ambigous positions in consensus sequence.