/ H3 / Variant: H3.Y

Description

H3.Y is involved in memory formation due to its presence in neurons in human hippocampus. One splice isoform has an extended C-terminal alpha tail that may interacts with the H2A.Z acidic patch
Alternate names: H3.X

Features

Below, you can explore the features of H3.Y from Homo sapiens, if available and how it compares to the canonical histones of the same type (first row). Canonical histone is shown in the first row, the names and descriptions of each feature can be found underneath. To explore variants from other species, please browse our curated sequences, automatically extracted sequences, or by taxonomy.

Keys: red - identical residues, blue - different residues (if more than one sequence).
Variant features
Y-motif
This motif distinguishes H3.Y from H3.3
General histone type features
alphaN
AlphaN-helix
R1
Minor groove arginine at the alphaN DNA binding site, SHL ±6.5
R2
Minor groove arginine at alpha1-alpha1 DNA binding site, SHL ±1.5
alpha1
Alpha1-helix, first helix of histone fold
loopL1
L1 loop connecting first and second helices of histone fold. Part of the L1L2 DNA binding site formed by H3 and H4 at SHL ±0.5.
beta1
Beta-strand in L1L2 DNA binding site
R3
Minor groove arginine at L1L2 DNA binding site, SHL ±2.5
alpha2
Alpha2-helix, second helix of histone fold
loopL2
L2 loop connecting second and third helices of histone fold. Part of L1L2 DNA binding site formed by H3 and H4 at SHL ±2.5.
beta2
Beta-strand in L1L2 DNA binding site
alpha3
Alpha3-helix, third helix of histone fold

References

  1. Talbert PB, Ahmad K, et al. "A unified phylogeny-based nomenclature for histone variants." Epigenetics Chromatin, 2012. PMID: 22650316
  2. Wiedemann SM, Mildner SN, et al. "Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y." J Cell Biol, 2010. PMID: 20819935
A set of manually selected and validated histone sequences is listed in the table. Click on an entry in the table to update the annotated sequence preview: a variant will be compared with the canonical histone from the same species (if available). Alternatively, tick mark the sequences and use toolbar to view MSA, export or add to basket. Use search or filters to find particular entries.
Keys: red - identical residues, blue - different residues (if more than one sequence). For feature legend see summary tab.
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Note: variant classification might be ambigous between very similar variants. Classification scores against all variant models are available via advanced menu.
Features characteristic for a given histone type/variant are marked below the consensus sequence. For feature description see summary tabs of the corresponding variants pages.
Keys: red - 80% identical, blue - 50% identical columns. X-ambigous positions in consensus sequence.