Description
H4 is one of the core histones. Two H4s and two H3s form H3-H4 tetramer via "hand shake" and "four helix bundle" motifs. Two H2A-H2B dimers then associate with H3-H4 tetramer to form complete nucleosome core. H4 is the most conservative histone type and has very few known variants. Structure of H4 has a histone fold domain and a flexible N-terminal tail. H4 provides sites for H2B interaction via "four-helix bundle" and forms a small β-sheet with H2Aa.Phylogenetic tree of variants (curated sequences)
Above, alignments of curated sequences from all H4 variants have been combined to construct the phylogenetic tree. Most of the variants cluster in separate clades. Click on the taxa name to learn more about its variant. A set of manually selected and validated histone sequences is listed in the table. Click on an entry in the table to update the annotated sequence preview: a variant will be compared with the canonical histone from the same species (if available).
Alternatively, tick mark the sequences and use toolbar to view MSA, export or add to basket. Use search or filters to find particular entries.
Keys: red - identical residues, blue - different residues (if more than one sequence). For feature legend see summary tab.
Sequence preview and annotation... LOADING
Note: variant classification might be ambigous between very similar variants. Classification scores against all variant models are available via advanced menu.
Features characteristic for a given histone type/variant are marked below the consensus sequence. For feature description see summary tabs of the corresponding variants pages.
Keys: red - 80% identical, blue - 50% identical columns. X-ambigous positions in consensus sequence.