/ H1 / Variant: H1.0

Description

H1.0 is a replication independent linker histone found in animals expressed in terminally differentiated cells. Has a common monophyletic origin that can be traced back before the differentiation between protostomes and deuterostomes, very early in metazoan evolution.
Alternate names: H1°, H1δ, H5, RI H1

Features

Below, you can explore the features of H1.0 from Homo sapiens, if available and how it compares to the canonical histones of the same type (first row). Canonical histone is shown in the first row, the names and descriptions of each feature can be found underneath. To explore variants from other species, please browse our curated sequences, automatically extracted sequences, or by taxonomy.

Keys: red - identical residues, blue - different residues (if more than one sequence).
General histone type features
alpha1
Alpha1-helix, first helix of winged helix-turn-helix domain
beta1
Beta-strand between two helices
alpha2
Alpha2-helix, second helix of winged helix-turn-helix domain
alpha3
Alpha3-helix
beta2
Beta-strand of short beta-sheet of C-terminal region
beta3
Beta-strand of short beta-sheet of C-terminal region
AKP helix
Positively charged carboxy-terminal domain involved in specific protein-protein and protein-DNA interactions, possibly plays roles in suppressing core histone tail domain acetylation in chromatin fiber.

References

  1. Talbert PB, Ahmad K, et al. "A unified phylogeny-based nomenclature for histone variants." Epigenetics Chromatin, 2012. PMID: 22650316
  2. Harshman SW, Young NL, et al. "H1 histones: current perspectives and challenges." Nucleic Acids Res, 2013. PMID: 23945933
  3. Pehrson JR and Cole RD. "Histone H1 subfractions and H10 turnover at different rates in nondividing cells." Biochemistry, 1982. PMID: 7066298
  4. Lieber T, Angerer LM, et al. "A histone H1 protein in sea urchins is encoded by a poly(A)+ mRNA." Proc Natl Acad Sci U S A, 1988. PMID: 2898141
A set of manually selected and validated histone sequences is listed in the table. Click on an entry in the table to update the annotated sequence preview: a variant will be compared with the canonical histone from the same species (if available). Alternatively, tick mark the sequences and use toolbar to view MSA, export or add to basket. Use search or filters to find particular entries.
Keys: red - identical residues, blue - different residues (if more than one sequence). For feature legend see summary tab.
Sequence preview and annotation... LOADING





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66.1
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Note: variant classification might be ambigous between very similar variants. Classification scores against all variant models are available via advanced menu.
Features characteristic for a given histone type/variant are marked below the consensus sequence. For feature description see summary tabs of the corresponding variants pages.
Keys: red - 80% identical, blue - 50% identical columns. X-ambigous positions in consensus sequence.